Antibiotic powder
Antibiotic powder
Aprazand®
Apramycin 50% Water-Soluble Powder
Composition
| Ingredient | Amount | Unit |
|---|---|---|
| Each gram of Aprazand® contains : | ||
| apramycin sulfate | 500 | mg |
Mechanism of action
Apramycin is a bactericidal aminoglycoside antibiotic. It binds irreversibly to the 30S subunit of the bacterial ribosome, inhibiting protein synthesis and disrupting cell membrane permeability.
It is primarily active against aerobic and facultative anaerobic Gram-negative bacteria e.g., Escherichia coli, Salmonella spp., Pseudomonas spp., Klebsiella spp., Proteus spp., Pasteurella spp. It also shows limited activity against certain Gram-positive bacteria, including some Staphylococcus species. Following oral administration, gastrointestinal absorption of apramycin is very low; the majority of the drug remains in the gut lumen, producing high local concentrations that make it particularly suitable for the treatment of enteric infections.
It is primarily active against aerobic and facultative anaerobic Gram-negative bacteria e.g., Escherichia coli, Salmonella spp., Pseudomonas spp., Klebsiella spp., Proteus spp., Pasteurella spp. It also shows limited activity against certain Gram-positive bacteria, including some Staphylococcus species. Following oral administration, gastrointestinal absorption of apramycin is very low; the majority of the drug remains in the gut lumen, producing high local concentrations that make it particularly suitable for the treatment of enteric infections.
Target species
Poultry, Calves and Lambs
Indications
Aprazand® is indicated for the treatment of gastrointestinal infections, such as colibacillosis and salmonellosis
Packaging
100 g multilayer aluminium sachets
Storage Conditions
Store in a dry place below 25°C, protected from direct light, in the original packaging. Once opened, keep the sachet tightly closed.
Dosage and Administration
• Poultry: 25–50 mg apramycin per kg body weight equivalent to 50–100 mg Aprazand® per kg body weight or 500 to 1000 g Aprazand® per 1000 litres of drinking water, for 7 consecutive days.
• Calves: 20–40 mg apramycin sulfate per kg body weight equivalent to 40 to 80 mg Aprazand® per kg body weight for 5 consecutive days.
• Lambs: 10 mg apramycin sulfate per kg body weight equivalent to 20 mg Aprazand® per kg body weight for 3 to 5 consecutive days.
• As directed by veterinarian.
• Calves: 20–40 mg apramycin sulfate per kg body weight equivalent to 40 to 80 mg Aprazand® per kg body weight for 5 consecutive days.
• Lambs: 10 mg apramycin sulfate per kg body weight equivalent to 20 mg Aprazand® per kg body weight for 3 to 5 consecutive days.
• As directed by veterinarian.
Withdrawal period
• Poultry: 7 days
• Calves and Lambs: 28 days
• Calves and Lambs: 28 days
Contraindications
Do not use in laying hens producing eggs for human consumption.
Precautions
• Medicated drinking water should be used within 24 hours.
• Keep out of the reach of children.
• Keep out of the reach of children.
Drug interactions
Concomitant use of Aprazand® with other aminoglycosides may increase the risk of nephrotoxicity.
Apramycin 50% Water-Soluble Powder