Antibiotic powder
Antibiotic powder
FOSFOZAND®
Fosfomycin Calcium 25% Water-Soluble Powder
Composition
| Ingredient | Amount | Unit |
|---|---|---|
| Each gram of FOSFOZAND® contains : | ||
| fosfomycin calcium | 250 | mg |
Mechanism of action
Fosfomycin is a broad-spectrum bactericidal antibiotic belonging to the phosphonic acid derivatives. After entering the bacterial cell through specific transport systems, it acts as a phosphoenolpyruvate (PEP) analogue and irreversibly inhibits UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) by covalently binding to the enzyme. Inhibition of this enzyme blocks the formation of peptidoglycan precursors, disrupts cell-wall synthesis, and ultimately causes bacterial lysis and death. Fosfomycin is not significantly metabolized and is predominantly excreted unchanged by the kidneys.
Fosfomycin is effective against a range of susceptible Gram-positive and Gram-negative bacteria, including Staphylococcus spp., Streptococcus spp., Escherichia coli, Salmonella spp., Pasteurella spp., Klebsiella spp., Shigella spp., and some susceptible strains of Ornithobacterium rhinotracheale.
Fosfomycin is effective against a range of susceptible Gram-positive and Gram-negative bacteria, including Staphylococcus spp., Streptococcus spp., Escherichia coli, Salmonella spp., Pasteurella spp., Klebsiella spp., Shigella spp., and some susceptible strains of Ornithobacterium rhinotracheale.
Target species
Poultry
Indications
FOSFOZAND® is indicated for the treatment of bacterial infections caused by microorganisms susceptible to fosfomycin, particularly gastrointestinal and respiratory tract infections, including colibacillosis, CRD complex, pasteurellosis, salmonellosis, infectious coryza, and staphylococcal infections.
Packaging
1 kg multilayer aluminium sachets
Storage Conditions
Store in a dry place below 25°C, protected from direct light, in the original packaging. Once opened, keep the sachet tightly closed.
Dosage and Administration
160 mg FOSFOZAND® per kg body weight, in the drinking water consumed during the first 6 to 8 hours of the day, for 3 to 5 consecutive days.
- As directed by a veterinarian.
- As directed by a veterinarian.
Withdrawal period
Meat and offal: 7 days
Contraindications
Do not use in laying hens producing eggs for human consumption.
Precautions
Medicated drinking water should be used within 24 hours.
Keep out of reach of children.
Keep out of reach of children.
Drug interactions
No significant drug interactions have been reported for FOSFOZAND® in poultry.
Synergistic effects of fosfomycin in combination with some beta-lactams, macrolides, tetracyclines, aminoglycosides, and quinolones have been observed.
Synergistic effects of fosfomycin in combination with some beta-lactams, macrolides, tetracyclines, aminoglycosides, and quinolones have been observed.
Fosfomycin Calcium 25% Water-Soluble Powder