Antibiotic solution
Antibiotic solution
METHOXYZAND®
Sulfadimethoxine 20% + Trimethoprim 4% Oral Solution
Composition
| Ingredient | Amount | Unit |
|---|---|---|
| Each ml of METHOXYZAND® contains : | ||
| sulfadimethoxine sodium | 200 | mg |
| trimethoprim | 40 | mg |
Mechanism of action
Sulfadimethoxine is an antibacterial agent belonging to the sulfonamide class with primarily bacteriostatic action. Structurally analogous to para-aminobenzoic acid (PABA), sulfonamides compete with it for the enzyme dihydropteroate synthase. Consequently, the formation of dihydrofolate and subsequent synthesis of tetrahydrofolate in bacteria are disrupted. Trimethoprim belongs to the diaminopyrimidines and selectively inhibits the bacterial dihydrofolate reductase enzyme, blocking the conversion of dihydrofolate (DHF) to tetrahydrofolate (THF). Tetrahydrofolate is an essential coenzyme for the synthesis of purines, thymidine, and other nucleotides required for bacterial DNA and RNA synthesis.
Therefore, the concurrent administration of sulfadimethoxine and trimethoprim produces sequential inhibition of two consecutive steps in the bacterial folic acid biosynthesis pathway. This sequential inhibition creates a synergistic antibacterial effect and markedly enhances the antimicrobial activity of the combination compared to each component alone. Under appropriate conditions and against susceptible microorganisms, this combination exerts a bactericidal effect.
The combination of sulfadimethoxine and trimethoprim possesses broad-spectrum antimicrobial activity against susceptible Gram-positive and Gram-negative bacteria, including Streptococcus spp., Staphylococcus spp., Escherichia coli, Pasteurella spp., Avibacterium paragallinarum, Salmonella spp., and Klebsiella spp.
Therefore, the concurrent administration of sulfadimethoxine and trimethoprim produces sequential inhibition of two consecutive steps in the bacterial folic acid biosynthesis pathway. This sequential inhibition creates a synergistic antibacterial effect and markedly enhances the antimicrobial activity of the combination compared to each component alone. Under appropriate conditions and against susceptible microorganisms, this combination exerts a bactericidal effect.
The combination of sulfadimethoxine and trimethoprim possesses broad-spectrum antimicrobial activity against susceptible Gram-positive and Gram-negative bacteria, including Streptococcus spp., Staphylococcus spp., Escherichia coli, Pasteurella spp., Avibacterium paragallinarum, Salmonella spp., and Klebsiella spp.
Target species
Broilers, Breeders, and Turkeys
Indications
METHOXYZAND® is indicated for the prevention, control, and treatment of infections caused by microorganisms susceptible to the sulfadimethoxine and trimethoprim combination in poultry, including streptococcal and staphylococcal infections, colibacillosis, infectious coryza, fowl cholera (pasteurellosis), and salmonellosis.
Packaging
1 L polyethylene bottles
Storage Conditions
Store below 25°C, protected from direct light, in the original packaging. After opening, keep the container cap tightly closed. Protect from freezing.
Dosage and Administration
500 ml of METHOXYZAND® per 1,000 L of drinking water for 3 to 5 consecutive days.
• As directed by a veterinarian.
• As directed by a veterinarian.
Withdrawal period
Meat and offal: 5 days
Contraindications
Do not use in laying hens producing eggs for human consumption.
Precautions
Medicated drinking water should be used within 24 hours.
Keep out of reach of children.
Keep out of reach of children.
Drug interactions
No known drug interactions have been reported at the recommended dosage.
Sulfadimethoxine 20% + Trimethoprim 4% Oral Solution