Antibiotic solution
Antibiotic solution
NEOZAND®
Neomycin Sulfate 20% Oral Solution
Composition
| Ingredient | Amount | Unit |
|---|---|---|
| Each ml of NEOZAND® contains : | ||
| neomycin sulfate | 200 | mg |
Mechanism of action
Neomycin is an aminoglycoside antibiotic. Following entry into the bacterial cell, it specifically binds to the 30S ribosomal subunit. Binding of neomycin interferes with formation of the translation initiation complex and causes misreading of mRNA, resulting in the synthesis of abnormal and nonfunctional proteins. This disruption of translation ultimately results in the bactericidal activity of neomycin. Uptake of neomycin into bacterial cells is an energy- and oxygen-dependent process; therefore, its activity is mainly directed against susceptible aerobic bacteria.
Following oral administration, neomycin is absorbed from the gastrointestinal tract only to a very limited extent, with most of the drug remaining within the gastrointestinal tract and being excreted unchanged in the feces. Consequently, orally administered neomycin acts predominantly within the gastrointestinal tract and may be used for the treatment of enteric infections caused by susceptible bacteria, particularly certain Gram-negative bacteria.
Following oral administration, neomycin is absorbed from the gastrointestinal tract only to a very limited extent, with most of the drug remaining within the gastrointestinal tract and being excreted unchanged in the feces. Consequently, orally administered neomycin acts predominantly within the gastrointestinal tract and may be used for the treatment of enteric infections caused by susceptible bacteria, particularly certain Gram-negative bacteria.
Target species
Broilers, Turkeys, Calves, Lambs, and Kids
Indications
NEOZAND® is indicated for the treatment of bacterial infections susceptible to neomycin, including bacterial enteritis caused by Escherichia coli; and secondary bacterial infections associated with blue comb disease in turkeys.
Packaging
1 L polyethylene bottles
Storage Conditions
Store below 25°C, protected from direct light, in the original packaging. After opening, keep the container cap tightly closed. Protect from freezing.
Dosage and Administration
Broilers
• From day 1 to 2 weeks of age: 1 liter of NEOZAND® per 4000 liters of drinking water for 3 to 5 consecutive days.
• From 3 to 5 weeks of age: 1 liter of NEOZAND® per 3000 liters of drinking water for 3 to 5 consecutive days.
• From 6 weeks of age to the end of the production period: 1 liter of NEOZAND® per 2000 liters of drinking water for 3 to 5 consecutive days.
Turkeys
• From 1 to 7 days of age: 1 liter of NEOZAND® per 2500 liters of drinking water for 3 to 5 consecutive days.
• From 2 to 8 weeks of age: 1 liter of NEOZAND® per 1500 liters of drinking water for 3 to 5 consecutive days.
• From 9 to 26 weeks of age: 1 liter of NEOZAND® per 1200 liters of drinking water for 3 to 5 consecutive days.
Calves, Lambs, and Kids
• 1 mL of NEOZAND® oral solution per 10 kg body weight, administered in drinking water for 3 to 5 consecutive days.
-As directed by a veterinarian.
• From day 1 to 2 weeks of age: 1 liter of NEOZAND® per 4000 liters of drinking water for 3 to 5 consecutive days.
• From 3 to 5 weeks of age: 1 liter of NEOZAND® per 3000 liters of drinking water for 3 to 5 consecutive days.
• From 6 weeks of age to the end of the production period: 1 liter of NEOZAND® per 2000 liters of drinking water for 3 to 5 consecutive days.
Turkeys
• From 1 to 7 days of age: 1 liter of NEOZAND® per 2500 liters of drinking water for 3 to 5 consecutive days.
• From 2 to 8 weeks of age: 1 liter of NEOZAND® per 1500 liters of drinking water for 3 to 5 consecutive days.
• From 9 to 26 weeks of age: 1 liter of NEOZAND® per 1200 liters of drinking water for 3 to 5 consecutive days.
Calves, Lambs, and Kids
• 1 mL of NEOZAND® oral solution per 10 kg body weight, administered in drinking water for 3 to 5 consecutive days.
-As directed by a veterinarian.
Withdrawal period
• Broiler: 7 days
• Turkeys: 14 days
• Calves, lambs, and kids: 30 days
• Turkeys: 14 days
• Calves, lambs, and kids: 30 days
Contraindications
Avoid use of NEOZAND® in cases of renal insufficiency and intestinal obstruction.
Precautions
Medicated drinking water should be used within 24 hours.
Keep out of reach of children.
Keep out of reach of children.
Drug interactions
Due to the increased risk of toxicity, avoid concomitant administration of NEOZAND® with other aminoglycosides, polymyxins, potent diuretics, or other drugs potentially causing nephrotoxicity or ototoxicity.
Concomitant use of NEOZAND® with macrolides and lincosamides is not recommended.
Concomitant use of vitamin K3 with NEOZAND® impairs the absorption of vitamin K3.
Concomitant use of NEOZAND® with macrolides and lincosamides is not recommended.
Concomitant use of vitamin K3 with NEOZAND® impairs the absorption of vitamin K3.
Neomycin Sulfate 20% Oral Solution