Antibiotic solution
Antibiotic solution
ColistiZand 2 ®
Colistin 2 000 000 IU Oral Solution
Composition
| Ingredient | Amount | Unit |
|---|---|---|
| Each ml of ColistiZand 2® oral solution contains : | ||
| colistin sulfate | 2 000 000 | IU |
Mechanism of action
Colistin is a polypeptide antibiotic in the polymyxin class with bactericidal activity primarily against Gram-negative bacteria. It binds to lipopolysaccharides (LPS) in the bacterial outer membrane, increasing membrane permeability and causing leakage of cellular contents and bacterial cell death. Binding to lipid A also neutralizes the endotoxic activity of LPS. After oral administration, colistin is negligibly absorbed systemically and remains predominantly in the intestinal lumen. It is therefore suitable for treating localized intestinal infections.
Target species
Poultry, calves, and lambs
Indications
ColistiZand 2® is indicated for the treatment of intestinal infections caused by Escherichia coli, Salmonella spp., and other Gram-negative bacteria susceptible to colistin.
Packaging
1 L polyethylene bottles
Storage Conditions
Store below 25°C, protected from direct light, in the original packaging. After opening, keep the container cap tightly closed. Protect from freezing.
Dosage and Administration
Poultry: 75000 IU of colistin per kg of body weight, equivalent to 37.5 ml of ColistiZand 2® per 1000 kg of body weight, or 250 ml of ColistiZand 2® per 1000 of drinking water, for 3 to 5 consecutive days.
Calves and lambs: 100000 IU of colistin per kg of body weight, equivalent to 5 ml of ColistiZand 2® per 100 kg of body weight, equivalent to 0.5 ml of ColistiZand 2® solution per 10 kg of body weight, administered in drinking water or milk for 3 to 4 consecutive days.
- As directed by the veterinarian
Calves and lambs: 100000 IU of colistin per kg of body weight, equivalent to 5 ml of ColistiZand 2® per 100 kg of body weight, equivalent to 0.5 ml of ColistiZand 2® solution per 10 kg of body weight, administered in drinking water or milk for 3 to 4 consecutive days.
- As directed by the veterinarian
Withdrawal period
Meat and offal: 2 days
Egg: 0 days
Egg: 0 days
Contraindications
Do not use ColistiZand 2® in horses, particularly in foals, since colistin, due to a shift in the gastrointestinal microflora balance could lead to the development of antimicrobial associated colitis (Colitis X), typically associated with Clostridium difficile, which may be fatal.
Do not use in animals with known hypersensitivity or resistance to colistin or other polymyxins.
Do not use in animals with known hypersensitivity or resistance to colistin or other polymyxins.
Precautions
Medicated drinking water should be used within 24 hours.
Keep out of reach of children.
Keep out of reach of children.
Drug interactions
Avoid Concomitant use of ColistiZand 2® with aminoglycosides, such as gentamicin and neomycin.
Concurrent use of ColistiZand 2® with levamisole is not recommended.
The efficacy of ColistiZand 2® may be reduced in the presence of divalent cations, such as iron, calcium, and magnesium.
Concurrent use of ColistiZand 2® with levamisole is not recommended.
The efficacy of ColistiZand 2® may be reduced in the presence of divalent cations, such as iron, calcium, and magnesium.
Colistin 2 000 000 IU Oral Solution