Anticoccidial powder
Anticoccidial powder
AMPROZAND®
Amprolium Hydrochloride 20% Water-Soluble Powder
Composition
| Ingredient | Amount | Unit |
|---|---|---|
| Each gram of AMPROZAND® contains : | ||
| amprolium hydrochloride | 200 | mg |
Mechanism of action
Amprolium is a quaternized pyrimidine derivative and a structural analogue of thiamine (vitamin B1) that acts as a competitive thiamine antagonist. By binding to the thiamine transport system in the parasite, it inhibits the uptake and utilization of thiamine, thereby disrupting carbohydrate metabolism and energy production in the parasite. A similar effect occurs in host cells, but to a much lesser extent.
Amprolium is primarily effective during the early stages of the Eimeria life cycle (especially the first three days) and exerts its greatest activity against trophozoites and first-generation schizonts within enterocytes. It interferes with asexual reproduction by preventing the differentiation of merozoites. It can also inhibit the sexual stages (gametogony) and reduce oocyst sporulation.
In poultry, amprolium exhibits high activity against Eimeria tenella and Eimeria acervulina. Its activity against Eimeria maxima, Eimeria necatrix, Eimeria brunetti, and Eimeria mivati is weaker. For this reason, it is frequently combined with ethopabate to broaden its spectrum of activity.
Amprolium is primarily effective during the early stages of the Eimeria life cycle (especially the first three days) and exerts its greatest activity against trophozoites and first-generation schizonts within enterocytes. It interferes with asexual reproduction by preventing the differentiation of merozoites. It can also inhibit the sexual stages (gametogony) and reduce oocyst sporulation.
In poultry, amprolium exhibits high activity against Eimeria tenella and Eimeria acervulina. Its activity against Eimeria maxima, Eimeria necatrix, Eimeria brunetti, and Eimeria mivati is weaker. For this reason, it is frequently combined with ethopabate to broaden its spectrum of activity.
Target species
Poultry, turkeys, calves, lambs and kids.
Indications
Each gram of AMPROZAND® contains 200 mg of amprolium hydrochloride.
Packaging
250 g multilayer aluminium sachets
Storage Conditions
Store in a dry place below 25°C, protected from direct light, in the original packaging. Once opened, keep the sachet tightly closed.
Dosage and Administration
Poultry and Turkeys
• Prevention: 100 g of AMPROZAND® in 300 liters of drinking water for 1 to 2 weeks
• Treatment: 100 g of AMPROZAND® in 80 to160 liters of drinking water for 5 to 7 consecutive days
Calves
• Prevention: 5 mg amprolium per kg body weight equivalent to 1 g of AMPROZAND® per 40 kg body weight for 21 consecutive days
• Treatment: 10 mg amprolium per kg body weight equivalent to 2 g of AMPROZAND® per 40 kg body weight for 5 consecutive days
Lambs and Kids
13 mg amprolium per kg body weight equivalent to 1 g of AMPROZAND® per 15 kg body weight for 5 consecutive days
- As directed by a veterinarian.
• Prevention: 100 g of AMPROZAND® in 300 liters of drinking water for 1 to 2 weeks
• Treatment: 100 g of AMPROZAND® in 80 to160 liters of drinking water for 5 to 7 consecutive days
Calves
• Prevention: 5 mg amprolium per kg body weight equivalent to 1 g of AMPROZAND® per 40 kg body weight for 21 consecutive days
• Treatment: 10 mg amprolium per kg body weight equivalent to 2 g of AMPROZAND® per 40 kg body weight for 5 consecutive days
Lambs and Kids
13 mg amprolium per kg body weight equivalent to 1 g of AMPROZAND® per 15 kg body weight for 5 consecutive days
- As directed by a veterinarian.
Withdrawal period
Meat and offal: 3 days
Contraindications
Do not use in laying hens producing eggs for human consumption.
Precautions
Prolonged administration of AMPROZAND® at doses higher than recommended may cause growth retardation, polyneuritis, and possible delay in the development of the immune system.
Medicated drinking water should be used within 24 hours.
Keep out of reach of children.
Medicated drinking water should be used within 24 hours.
Keep out of reach of children.
Drug interactions
Concomitant use of AMPROZAND® with dietary supplements containing vitamin B1 (thiamine) must be avoided, as it decreases the efficacy of amprolium.
Amprolium Hydrochloride 20% Water-Soluble Powder