Anticoccidial powder
Anticoccidial powder
AMPROZAND PLUS®
Amprolium 25% + Ethopabate 1.6% in-feed powder
Composition
| Ingredient | Amount | Unit |
|---|---|---|
| Each gram of AMPROZAND PLUS® contains : | ||
| amprolium hydrochloride | 250 | mg |
| ethopabate | 16 | mg |
Mechanism of action
Amprolium is a structural analogue of thiamine (vitamin B1) and a coccidiostat that competitively inhibits the uptake and utilization of thiamine in developing stages of coccidia, especially merozoites and second-generation schizonts. Consequently, the availability of thiamine and the formation of thiamine pyrophosphate, required for essential metabolic reactions, are disrupted, and the growth and reproduction of Eimeria are inhibited. Amprolium is particularly effective against replicating schizont stages.
Ethopabate is an anticoccidial compound and a folic acid pathway antagonist that disrupts nucleic acid synthesis and cell proliferation in Eimeria by interfering with the folate metabolism pathway and the related para-aminobenzoic acid (PABA) pathway. Ethopabate exhibits significant activity against certain intestinal species, particularly Eimeria maxima and Eimeria brunetti. Due to its limited activity against the caecal stages of Eimeria tenella, it is usually used in combination with amprolium.
The combination of amprolium and ethopabate utilizes two different mechanisms, broadening the anticoccidial spectrum of activity and enabling the control of a wider range of important Eimeria species.
Ethopabate is an anticoccidial compound and a folic acid pathway antagonist that disrupts nucleic acid synthesis and cell proliferation in Eimeria by interfering with the folate metabolism pathway and the related para-aminobenzoic acid (PABA) pathway. Ethopabate exhibits significant activity against certain intestinal species, particularly Eimeria maxima and Eimeria brunetti. Due to its limited activity against the caecal stages of Eimeria tenella, it is usually used in combination with amprolium.
The combination of amprolium and ethopabate utilizes two different mechanisms, broadening the anticoccidial spectrum of activity and enabling the control of a wider range of important Eimeria species.
Target species
Broilers, layers pullets, and turkeys
Indications
AMPROZAND PLUS® is indicated for the prevention and treatment of coccidiosis caused by susceptible Eimeria species in chickens and turkeys. In chickens, it is primarily effective against Eimeria tenella, Eimeria acervulina, Eimeria maxima, Eimeria brunetti, and Eimeria necatrix. AMPROZAND PLUS® is effective against Eimeria adenoeides, Eimeria meleagrimitis, and Eimeria gallopavonis in turkeys.
Packaging
1 kg multilayer aluminium sachets
Storage Conditions
Store in a dry place below 25°C, protected from direct light, in the original packaging. Once opened, keep the sachet tightly closed.
Dosage and Administration
Broilers and Turkeys
500 g of AMPROZAND PLUS® per ton of feed.
Replacement Pullets and Layer pullets
• Up to 6 weeks of age: 400 g of AMPROZAND PLUS® per ton of feed.
• From 6 to 12 weeks of age: 325 g of AMPROZAND PLUS® per ton of feed.
• From 12 to 18 weeks of age: 250 g of AMPROZAND PLUS® per ton of feed.
- As directed by a veterinarian.
500 g of AMPROZAND PLUS® per ton of feed.
Replacement Pullets and Layer pullets
• Up to 6 weeks of age: 400 g of AMPROZAND PLUS® per ton of feed.
• From 6 to 12 weeks of age: 325 g of AMPROZAND PLUS® per ton of feed.
• From 12 to 18 weeks of age: 250 g of AMPROZAND PLUS® per ton of feed.
- As directed by a veterinarian.
Withdrawal period
Meat and offal: 3 days.
Contraindications
Do not use in laying hens producing eggs for human consumption.
Precautions
Prolonged administration of AMPROZAND PLUS® at doses higher than recommended may cause growth retardation or polyneuritis, and may also delay the development of the immune system.
Drug interactions
Concomitant use of AMPROZAND PLUS® with dietary supplements containing vitamin B1 (thiamine) must be avoided, as it decreases the efficacy of amprolium.
Direct mixing of AMPROZAND PLUS® with high volumes of choline chloride as a concentrated premix is not recommended, as choline chloride, due to its hygroscopic nature, can cause the degradation of amprolium. This issue does not occur in the final complete feed.
The presence of bentonite in the feed can reduce the efficacy of AMPROZAND PLUS® .
Direct mixing of AMPROZAND PLUS® with high volumes of choline chloride as a concentrated premix is not recommended, as choline chloride, due to its hygroscopic nature, can cause the degradation of amprolium. This issue does not occur in the final complete feed.
The presence of bentonite in the feed can reduce the efficacy of AMPROZAND PLUS® .
Amprolium 25% + Ethopabate 1.6% in-feed powder