Anticoccidial powder
Anticoccidial powder
MaducarbaZand®
Maduramicin ammonium 0.75% + Nicarbazin 8% Granulated premix
Composition
| Ingredient | Amount | Unit |
|---|---|---|
| Each gram of Maducarbazand® contains : | ||
| maduramicin ammonium | 7.5 | mg |
| nicarbazin | 80 | mg |
Mechanism of action
Maduramicin is a monovalent glycosidic polyether ionophore anticoccidial that forms complexes with cations such as Na+ and K+ thereby increasing their transport across the biological membranes of Eimeria. Consequently, the parasite’s ionic and osmotic balance is disrupted, and impairment of energy-dependent processes leads to cellular damage and death of the sensitive parasitic stages. Maduramicin acts predominantly on the early asexual stages of Eimeria, halting the progression of the parasite’s life cycle.
Nicarbazin is a chemical anticoccidial belonging to the carbanilide class and is an equimolar complex of 4,4′-dinitrocarbanilide (DNC) and 2-hydroxy-4,6-dimethylpyrimidine (DMP). Although its exact mode of action is not fully elucidated, it inhibits the growth and development of the parasite by interfering with Eimeria energy metabolism, ATP-dependent processes, and calcium homeostasis. The effect of nicarbazin is primarily directed against schizogony stages and schizont development.
The combination of maduramicin and nicarbazin, with their distinct modes of action, provides synergistic efficacy across multiple metabolic pathways and developmental stages of the Eimeria life cycle.
Nicarbazin is a chemical anticoccidial belonging to the carbanilide class and is an equimolar complex of 4,4′-dinitrocarbanilide (DNC) and 2-hydroxy-4,6-dimethylpyrimidine (DMP). Although its exact mode of action is not fully elucidated, it inhibits the growth and development of the parasite by interfering with Eimeria energy metabolism, ATP-dependent processes, and calcium homeostasis. The effect of nicarbazin is primarily directed against schizogony stages and schizont development.
The combination of maduramicin and nicarbazin, with their distinct modes of action, provides synergistic efficacy across multiple metabolic pathways and developmental stages of the Eimeria life cycle.
Target species
Broilers and layers pullets
Indications
Maducarbazand® is indicated for the prevention of coccidiosis caused by susceptible species of Eimeria, including Eimeria tenella, E. necatrix, E. acervulina, E. brunetti, E. maxima, and E. mitis (mivati).
Packaging
5 kg multilayer aluminium sachets
Storage Conditions
Store in a dry place below 25°C, protected from direct light, in the original packaging. Once opened, keep the sachet tightly closed.
Dosage and Administration
3.75 mg maduramicin ammonium and 40 mg nicarbazin per kg of feed equivalent to 500 g of Maducarbazand® per ton of feed
- As directed by a veterinarian.
- As directed by a veterinarian.
Withdrawal period
• Meat and offal: 5 days
• Layers pullets: Discontinue Maducarbazand® after 16 weeks of age.
• Layers pullets: Discontinue Maducarbazand® after 16 weeks of age.
Contraindications
• Do not use in laying hens producing eggs for human consumption.
• Fatal in horses and other equines.
• Fatal in horses and other equines.
Precautions
• Concomitant use of Maducarbazand® with tiamulin should be undertaken with caution.
• Exceeding the recommended dosage of Maducarbazand®may cause signs of toxicity, including reduced feed intake and impaired growth rate.
• To ensure thorough and uniform mixing, it is recommended to pre-mix 500 g of Maducarbazand® thoroughly with 20 to 50 kg of feed ingredients before incorporating it into the final 1 ton feed batch.
• Wear gloves, eye protection, and appropriate respiratory protective equipment when handling Maducarbazand®. Avoid inhalation of dust and contact with skin and eyes.
• Keep out of reach of children.
• Exceeding the recommended dosage of Maducarbazand®may cause signs of toxicity, including reduced feed intake and impaired growth rate.
• To ensure thorough and uniform mixing, it is recommended to pre-mix 500 g of Maducarbazand® thoroughly with 20 to 50 kg of feed ingredients before incorporating it into the final 1 ton feed batch.
• Wear gloves, eye protection, and appropriate respiratory protective equipment when handling Maducarbazand®. Avoid inhalation of dust and contact with skin and eyes.
• Keep out of reach of children.
Drug interactions
Maducarbazand® should not be used concomitantly with other other ionophore coccidiostats.
Maduramicin ammonium 0.75% + Nicarbazin 8% Granulated premix