Anticoccidial powder
Anticoccidial powder
MaduraZand®
Maduramicin ammonium 1% granulated premix
Composition
| Ingredient | Amount | Unit |
|---|---|---|
| Each gram of MaduraZand® contains : | ||
| maduramicin ammonium | 10 | mg |
Mechanism of action
Maduramicin is a monovalent glycoside polyether ionophore and one of the most potent ionophores used in poultry. It acts by forming complexes with monovalent cations, particularly sodium (Na +) and potassium (K +) ions, facilitating their transport across the biological membranes of the parasite. Consequently, the natural electrochemical potential and ion gradients across the cellular membrane of Eimeria are disrupted, leading to the breakdown of ionic and osmotic homeostasis.
This disruption results in an abnormal accumulation of ions within the parasite’s cells, impairment of energy-dependent cellular processes, and structural and functional damage, ultimately leading to swelling, membrane destruction, and death of susceptible parasitic stages.
Maduramicin is effective against both intracellular and extracellular stages of the Eimeria life cycle, particularly the early asexual stages. By impeding their growth and development, it halts the propagation of the parasite and prevents the incidence and severity of coccidiosis
This disruption results in an abnormal accumulation of ions within the parasite’s cells, impairment of energy-dependent cellular processes, and structural and functional damage, ultimately leading to swelling, membrane destruction, and death of susceptible parasitic stages.
Maduramicin is effective against both intracellular and extracellular stages of the Eimeria life cycle, particularly the early asexual stages. By impeding their growth and development, it halts the propagation of the parasite and prevents the incidence and severity of coccidiosis
Target species
Broilers
Indications
MaduraZand® is indicated for the prevention of coccidiosis caused by susceptible species of Eimeria, including Eimeria tenella, E. necatrix, E. acervulina, E. brunetti, E. maxima, and E. mitis (E. mivati) in broilers.
Packaging
5 kg multilayer aluminium sachets
Storage Conditions
Store in a dry place below 25°C, protected from direct light, in the original packaging. Once opened, keep the sachet tightly closed.
Dosage and Administration
5 mg of maduramicin per kg of feed equivalent to 500 g of MaduraZand® per ton of feed
- As directed by a veterinarian.
- As directed by a veterinarian.
Withdrawal period
• Meat and offal: 5 days
Contraindications
• Do not use in laying hens producing eggs for human consumption.
• Fatal in horses and other equines.
• Fatal in horses and other equines.
Precautions
• Concomitant use of MaduraZand® with tiamulin at recommended doses produces substantially less interaction and toxicity compared to some other polyether ionophores such as monensin, narasin, and salinomycin.
• Exceeding the recommended dosage of MaduraZand® may lead to symptoms of toxicosis, including reduced feed intake and depressed growth rates.
• To ensure thorough and uniform mixing, it is recommended to prepare a pre-blend by mixing 500 g of MaduraZand® with 20 to 50 kg of feed ingredients before incorporating it into the final ton of complete feed.
• Avoid inhalation of MaduraZand® dust and prevent contact with eyes and skin.
• Keep out of reach of children.
• Exceeding the recommended dosage of MaduraZand® may lead to symptoms of toxicosis, including reduced feed intake and depressed growth rates.
• To ensure thorough and uniform mixing, it is recommended to prepare a pre-blend by mixing 500 g of MaduraZand® with 20 to 50 kg of feed ingredients before incorporating it into the final ton of complete feed.
• Avoid inhalation of MaduraZand® dust and prevent contact with eyes and skin.
• Keep out of reach of children.
Drug interactions
• Concomitant use of MaduraZand® with florfenicol may decrease plasma concentrations of florfenicol.
• MaduraZand® should not be used concomitantly with other other ionophore coccidiostats.
• MaduraZand® should not be used concomitantly with other other ionophore coccidiostats.
Maduramicin ammonium 1% granulated premix