Anticoccidial powder
Anticoccidial powder
SalinoZand®
Salinomycin Sodium 12% Granulated Premix
Composition
| Ingredient | Amount | Unit |
|---|---|---|
| Each gram of SalinoZand® contains : | ||
| salinomycin sodium | 120 | mg |
Mechanism of action
Salinomycin is a polyether monocarboxylic ionophore coccidiostat obtained from the fermentation of Streptomyces albus.
Salinomycin forms lipid-soluble complexes with monovalent cations, particularly potassium (K⁺) and sodium (Na⁺), facilitating the transport of these ions across biological membranes. Consequently, parasite membrane permeability to cations is altered, disrupting ionic gradients and the normal transmembrane electrical potential of the cell.
The disturbance in intra- and extracellular ion balance leads to impaired ionic and osmotic homeostasis, as well as impairment of energy-dependent metabolic processes. Following these alterations, the parasite cell is unable to maintain ionic equilibrium and normal physiological function, leading to cellular damage and ultimately the death of susceptible parasite stages.
Salinomycin acts on both extracellular and intracellular stages of the Eimeria life cycle, particularly the early asexual stages. The resulting disruption in ion transport and cellular function inhibits the growth and development of sensitive stages of the parasite, preventing effective progression of the infection and thereby reducing the severity of coccidiosis.
Salinomycin forms lipid-soluble complexes with monovalent cations, particularly potassium (K⁺) and sodium (Na⁺), facilitating the transport of these ions across biological membranes. Consequently, parasite membrane permeability to cations is altered, disrupting ionic gradients and the normal transmembrane electrical potential of the cell.
The disturbance in intra- and extracellular ion balance leads to impaired ionic and osmotic homeostasis, as well as impairment of energy-dependent metabolic processes. Following these alterations, the parasite cell is unable to maintain ionic equilibrium and normal physiological function, leading to cellular damage and ultimately the death of susceptible parasite stages.
Salinomycin acts on both extracellular and intracellular stages of the Eimeria life cycle, particularly the early asexual stages. The resulting disruption in ion transport and cellular function inhibits the growth and development of sensitive stages of the parasite, preventing effective progression of the infection and thereby reducing the severity of coccidiosis.
Target species
Poultry
Indications
SalinoZand® is indicated for the prevention of coccidiosis caused by susceptible Eimeria species, including Eimeria tenella, Eimeria necatrix, Eimeria acervulina, Eimeria brunetti, Eimeria maxima, and Eimeria mitis in broilers and layer pullets.
Packaging
5 kg multilayer aluminium sachets
Storage Conditions
Store in a dry place below 25°C, protected from direct light, in the original packaging. Once opened, keep the sachet tightly closed.
Dosage and Administration
60 mg salinomycin per kg of feed or 500 g of SalinoZand® per ton of feed.
- As directed by a veterinarian.
- As directed by a veterinarian.
Withdrawal period
Meat and offal: 5 days
Layers pullets: 7 days before the onset of the laying period.
Layers pullets: 7 days before the onset of the laying period.
Contraindications
• Do not use in laying birds producing eggs for human consumption.
• Administration of SalinoZand® to turkeys, horses, and other equines is fatal.
• Administration of SalinoZand® to turkeys, horses, and other equines is fatal.
Precautions
• When handling SalinoZand®, wear gloves, eye protection, and appropriate respiratory protective equipment.
• Avoid inhalation of SalinoZand® dust and prevent contact with eyes and skin.
• Keep out of the reach of children.
• Avoid inhalation of SalinoZand® dust and prevent contact with eyes and skin.
• Keep out of the reach of children.
Drug interactions
• Concomitant use of SalinoZand® with tiamulin is strictly contraindicated. An interval of at least 7 days must be observed between the sequential administration of these two medicinal products.
• Concomitant use of SalinoZand® with erythromycin and certain sulfonamides (such as sulfaquinoxaline) is not recommended due to the potential risk of increased salinomycin toxicity.
• Concomitant use of SalinoZand® with florfenicol may decrease plasma concentrations of florfenicol.
• SalinoZand® should not be used concomitantly with other other ionophore coccidiostats.
• Concomitant use of SalinoZand® with erythromycin and certain sulfonamides (such as sulfaquinoxaline) is not recommended due to the potential risk of increased salinomycin toxicity.
• Concomitant use of SalinoZand® with florfenicol may decrease plasma concentrations of florfenicol.
• SalinoZand® should not be used concomitantly with other other ionophore coccidiostats.
Salinomycin Sodium 12% Granulated Premix