Anticoccidial solution
Anticoccidial solution
Toltrazand®
Each ml of Toltrazand® contains 25 mg of toltrazuril.
Composition
| Ingredient | Amount | Unit |
|---|---|---|
| Each ml of Toltrazand® contains : | ||
| toltrazuril | 25 | mg |
Mechanism of action
Toltrazuril is an anticoccidial drug belonging to the triazinetrione group that acts against various stages of intracellular development of parasites of the genus Eimeria. By reducing the activity of the parasite’s respiratory-chain enzymes, this drug causes structural and functional alterations in the parasite cell. These alterations include swelling of the endoplasmic reticulum and Golgi apparatus, changes in the perinuclear space, and disruption of nuclear division.
Toltrazuril is effective against various stages of intracellular growth and development of Eimeria, including schizogony (asexual multiplication) and gametogony (the sexual stage). In schizonts and microgametes, disruption of nuclear division and damage to cellular structures are observed. In addition, in macrogametes, damage to wall-forming bodies interferes with the formation of a normal oocyst wall.
At different stages of intracellular development, toltrazuril causes swelling of the endoplasmic reticulum and the formation of numerous vacuoles. These effects on various intracellular stages of the parasite result in toltrazuril having a predominantly coccidiocidal effect.
Toltrazuril is effective against various stages of intracellular growth and development of Eimeria, including schizogony (asexual multiplication) and gametogony (the sexual stage). In schizonts and microgametes, disruption of nuclear division and damage to cellular structures are observed. In addition, in macrogametes, damage to wall-forming bodies interferes with the formation of a normal oocyst wall.
At different stages of intracellular development, toltrazuril causes swelling of the endoplasmic reticulum and the formation of numerous vacuoles. These effects on various intracellular stages of the parasite result in toltrazuril having a predominantly coccidiocidal effect.
Target species
Broilers and turkeys
Indications
Toltrazand® is indicated for the treatment of coccidiosis caused by susceptible Eimeria species, including Eimeria tenella, Eimeria maxima, Eimeria acervulina, Eimeria necatrix, Eimeria brunetti, and Eimeria mitis in chickens, as well as Eimeria meleagrimitis and Eimeria adenoeides in turkeys.
Packaging
1 L polyethylene bottles
Storage Conditions
Store below 25°C, protected from direct light, in the original packaging. After opening, keep the container cap tightly closed. Protect from freezing.
Dosage and Administration
The recommended dose is 7 mg of toltrazuril per kg of body weight per day for 2 consecutive days. This is generally equivalent to 1 ml of Toltrazand® per liter of drinking water for continuous administration over 48 hours, or 3 ml of Toltrazand® per liter of drinking water for administration over 8 hours per day for 2 consecutive days.
- As directed by a veterinarian
- As directed by a veterinarian
Withdrawal period
Broilers: 14 days
Turkeys: 16 days
Turkeys: 16 days
Contraindications
Do not use in laying hens producing eggs for human consumption.
Precautions
Toltrazand® is an alkaline solution; contact with the skin and eyes should be avoided. In case of contact, immediately rinse the affected area with plenty of water.
During the treatment period, medicated water must be the sole source of drinking water for the birds.
Medicated drinking water should be used within 24 hours.
Keep out of the reach of children.
During the treatment period, medicated water must be the sole source of drinking water for the birds.
Medicated drinking water should be used within 24 hours.
Keep out of the reach of children.
Drug interactions
No known drug interactions have been reported for Toltrazand®.
Each ml of Toltrazand® contains 25 mg of toltrazuril.