Antibiotic powder
Antibiotic powder
ColistiZand 3®
Colistin 3 000 000 IU Water-Soluble Powder
Composition
| Ingredient | Amount | Unit |
|---|---|---|
| Each gram of ColistiZand 3® contains : | ||
| colistin sulfate | 3 000 000 | IU |
Mechanism of action
Colistin is a polypeptide antibiotic belonging to the polymyxin class that primarily exhibits bactericidal activity against Gram-negative bacteria. By binding to lipopolysaccharides in the bacterial outer membrane, it disrupts membrane permeability, leading to the leakage of intracellular contents and bacterial cell death. In addition, the binding of polymyxins to lipid A neutralizes the endotoxic activity of bacterial lipopolysaccharides (LPS). Following oral administration, colistin undergoes negligible systemic absorption and remains largely within the gastrointestinal lumen, making it suitable for the local treatment of enteric infections.
Target species
Poultry
Indications
ColistiZand 3® is indicated for the treatment of gastrointestinal infections caused by Escherichia coli, Salmonella spp., and other Gram-negative bacteria susceptible to colistin.
Packaging
100 g multilayer aluminium sachets
Storage Conditions
Store in a dry place below 25°C, protected from direct light, in the original packaging. Once opened, keep the sachet tightly closed.
Dosage and Administration
In drinking water: 75000 IU of colistin per kg of body weight, equivalent to 25 g of ColistiZand 3® per 1000 kg of body weight, or 100 g of ColistiZand 3® per 500 liters of drinking water for 5 to 7 consecutive days.
Mixed in feed: 75000 IU of colistin sulfate per kg of body weight, equivalent to 25 g of ColistiZand 3® per 1000 kg of body weight, or 100 g of ColistiZand 3® per 250 kg of complete feed for 5 to 7 consecutive days.
- As directed by a veterinarian.
Mixed in feed: 75000 IU of colistin sulfate per kg of body weight, equivalent to 25 g of ColistiZand 3® per 1000 kg of body weight, or 100 g of ColistiZand 3® per 250 kg of complete feed for 5 to 7 consecutive days.
- As directed by a veterinarian.
Withdrawal period
Meat and offal: 2 days
Egg: 0 days
Egg: 0 days
Contraindications
Do not use ColistiZand 3® in horses, particularly in foals, since colistin, due to a shift in the gastrointestinal microflora balance could lead to the development of antimicrobial associated colitis (Colitis X), typically associated with Clostridium difficile, which may be fatal.
Do not use in animals with known hypersensitivity or resistance to colistin or other polymyxins.
Do not use in animals with known hypersensitivity or resistance to colistin or other polymyxins.
Precautions
Medicated drinking water should be used within 24 hours.
Keep out of reach of children.
Keep out of reach of children.
Drug interactions
Avoid concurrent administration of ColistiZand 3® with aminoglycosides such as gentamicin and neomycin.
Concomitant use of ColistiZand 3® with levamisole is not recommended.
The efficacy of ColistiZand 3® may be reduced in the presence of divalent cations such as iron, calcium, and magnesium.
Concomitant use of ColistiZand 3® with levamisole is not recommended.
The efficacy of ColistiZand 3® may be reduced in the presence of divalent cations such as iron, calcium, and magnesium.
Colistin 3 000 000 IU Water-Soluble Powder