Antibiotic solution
Antibiotic solution
DoxyZand10®
Doxycycline 10% Oral Solution
Composition
| Ingredient | Amount | Unit |
|---|---|---|
| Each mL of DoxyZand10® solution contains : | ||
| Doxycycline Hyclat | 100 | mg |
Mechanism of action
Doxycycline is a semi-synthetic antibiotic of the tetracycline class. Tetracyclines are primarily bacteriostatic antibiotics that inhibit bacterial protein synthesis by reversibly binding to the 30S ribosomal subunit of susceptible bacteria. Doxycycline inhibits the addition of amino acids to the growing peptide chain by preventing the binding of aminoacyl-tRNA to the A site of the ribosome–mRNA complex, thereby inhibiting protein synthesis and bacterial growth.
Doxycycline has a broad spectrum of activity against susceptible Gram-positive and Gram-negative bacteria and is active against certain species of Salmonella, Escherichia coli, and Pasteurella, as well as certain Gram-positive bacteria, including Staphylococcus spp., Streptococcus spp., and Clostridium spp. It is also active against certain cell-wall-deficient or intracellular microorganisms, including some species of Mycoplasma, Chlamydia, and Rickettsia.
Following oral administration in poultry, doxycycline is rapidly and extensively absorbed from the gastrointestinal tract and, after absorption, is widely distributed throughout various tissues of the body. Therefore, it may be suitable for the treatment of respiratory and systemic infections caused by susceptible microorganisms.
Doxycycline has a broad spectrum of activity against susceptible Gram-positive and Gram-negative bacteria and is active against certain species of Salmonella, Escherichia coli, and Pasteurella, as well as certain Gram-positive bacteria, including Staphylococcus spp., Streptococcus spp., and Clostridium spp. It is also active against certain cell-wall-deficient or intracellular microorganisms, including some species of Mycoplasma, Chlamydia, and Rickettsia.
Following oral administration in poultry, doxycycline is rapidly and extensively absorbed from the gastrointestinal tract and, after absorption, is widely distributed throughout various tissues of the body. Therefore, it may be suitable for the treatment of respiratory and systemic infections caused by susceptible microorganisms.
Target species
Broiler poultry
Indications
DoxyZand10® is indicated for the treatment of bacterial respiratory and gastrointestinal infections caused by microorganisms sensitive to doxycycline, including CRD caused by Mycoplasma, colibacillosis, pasteurellosis, salmonellosis, infectious coryza، necrotic enteritis, air sac infections, and staphylococcal infections.
Packaging
1 L polyethylene bottles
Storage Conditions
Store below 25°C, protected from direct light, in the original packaging. After opening, keep the container cap tightly closed. Protect from freezing.
Dosage and Administration
10 to 20 mg of doxycycline per kg of body weight, or 500 to 1000 ml of DoxyZand10® in every 1000 liters of drinking water for 3 to 5 consecutive days.
-As directed by veterinarian.
-As directed by veterinarian.
Withdrawal period
Meat and offal: 5 days
Contraindications
Do not use in laying hens producing eggs for human consumption.
Precautions
Medicated drinking water should be used within 24 hours.
Keep out of reach of children.
Keep out of reach of children.
Drug interactions
Concomitant use of DoxyZand10® with aminoglycosides, penicillins, and cephalosporins is not recommended due to antagonism and reduced antimicrobial efficacy.
The effect of DoxyZand10® may be reduced in the presence of divalent and trivalent cations such as iron, calcium, and magnesium.
The effect of DoxyZand10® may be reduced in the presence of divalent and trivalent cations such as iron, calcium, and magnesium.
Doxycycline 10% Oral Solution