Antibiotic solution
Antibiotic solution
TILMOZAND®
Tilmicosin 25% Oral Solution
Composition
| Ingredient | Amount | Unit |
|---|---|---|
| Each ml of TILMOZAND® contains | ||
| tilmicosin phosphate | 250 | mg |
Mechanism of action
Tilmicosin is a semisynthetic antibiotic of the macrolide class that acts by reversibly binding to the 50S subunit of the ribosome of susceptible bacteria and inhibiting peptide bond formation, thereby disrupting protein synthesis. Macrolides are generally bacteriostatic, but at high concentrations they may exhibit bactericidal activity.
Tilmicosin is primarily active against susceptible Gram-positive bacteria as well as certain Gram-negative bacteria, particularly Pasteurella multocida, and is also effective against Mycoplasma spp. Tilmicosin accumulates in lung tissue and produces high concentrations in this tissue.
Tilmicosin is primarily active against susceptible Gram-positive bacteria as well as certain Gram-negative bacteria, particularly Pasteurella multocida, and is also effective against Mycoplasma spp. Tilmicosin accumulates in lung tissue and produces high concentrations in this tissue.
Target species
Broilers
Indications
TILMOZAND® is indicated for the treatment of respiratory infections in poultry caused by Mycoplasma spp., Pasteurella spp., susceptible strains of Ornithobacterium rhinotracheale (ORT), and other susceptible bacteria.
Packaging
240 ml polyethylene bottles
Storage Conditions
Store below 25°C, protected from direct light, in the original packaging. After opening, keep the container cap tightly closed. Protect from freezing.
Dosage and Administration
75 mg of tilmicosin per liter of drinking water, equivalent to 15 to 20 mg of tilmicosin phosphate per kg body weight per day, or:
- One 60 mL bottle of TILMOZAND® in 200 liters of drinking water.
- One 240 mL bottle of TILMOZAND® in 800 liters of drinking water.
Administer for 3 consecutive days. If necessary, treatment may be repeated for an additional 1 to 2 days.
- As directed by the veterinarian.
- One 60 mL bottle of TILMOZAND® in 200 liters of drinking water.
- One 240 mL bottle of TILMOZAND® in 800 liters of drinking water.
Administer for 3 consecutive days. If necessary, treatment may be repeated for an additional 1 to 2 days.
- As directed by the veterinarian.
Withdrawal period
Meat and offal: 12 days
Contraindications
Do not use in laying hens producing eggs for human consumption.
Avoid use of TILMOZAND® in horses due to the risk of severe toxicity.
Avoid use of TILMOZAND® in horses due to the risk of severe toxicity.
Precautions
Medicated drinking water should be used within 24 hours.
Keep out of reach of children.
Keep out of reach of children.
Drug interactions
Concomitant use of TILMOZAND® with florfenicol, lincosamides, other macrolides, penicillins, and cephalosporins is not recommended due to antagonism and reduced antimicrobial efficacy.
Tilmicosin 25% Oral Solution