Antiparasitic
Antiparasitic
ExoZand®
Fluralaner 1% Oral Solution
Composition
| Ingredient | Amount | Unit |
|---|---|---|
| Each ml of ExoZand® contains : | ||
| fluralaner | 10 | mg |
Mechanism of action
Fluralaner is an acaricide and insecticide belonging to the isoxazoline group, which acts by inhibiting gamma-aminobutyric acid (GABA)-gated chloride channels and glutamate-gated chloride channels. This inhibitory effect exhibits significant selectivity against insect neurons compared with mammalian neurons. Inhibition of these channels leads to uncontrolled neuronal activity and ultimately results in the paralysis and death of fleas and mites. Fluralaner is highly effective in controlling poultry red mite (Dermanyssus gallinae) infestations in chickens. Fluralaner demonstrates a lethal effect on mites within 4 hours after mites feed on treated chickens, and this efficacy is maintained for at least 14 days following the first administration. Adult mites are eliminated rapidly, whereas non-feeding eggs and larvae present at the time of treatment are killed by the lethal effect of fluralaner upon reaching maturity, developing into nymphs, and beginning blood feeding. Furthermore, egg production in female mites is halted for up to 15 days following the first administration. It has been reported that mite populations decrease by up to 99% within 3 days after the first administration and by up to 100% within 2 days after the second administration.
Target species
Pullets, layers and breeders
Indications
ExoZand® is indicated for the treatment and control of poultry red mite (Dermanyssus gallinae) infestations.
Packaging
1 liter Polyethylene bottles
Storage Conditions
Store below 25°C, away from direct sunlight, and in the original container. Close the container cap tightly after opening. Protect from freezing.
Dosage and Administration
0.5 mg of fluralaner, equivalent to 0.05 ml of ExoZand® per kg of body weight, administered via drinking water. Treatment must be repeated 7 days after the initial administration.
Withdrawal period
Meat and offal: 13 days
Eggs: 0 days
Eggs: 0 days
Contraindications
This product is safe for use in poultry and has no withdrawal period or restriction during the egg-laying period.
Precautions
• Medicated drinking water should be used within 24 hours.
• Strict adherence to the recommended dosage is essential to prevent adverse effects on production performance.
• Keep out of reach of children.
• Strict adherence to the recommended dosage is essential to prevent adverse effects on production performance.
• Keep out of reach of children.
Drug interactions
No known drug interactions have been reported with fluralaner; however, avoid mixing ExoZand® with other veterinary medicinal products.
Fluralaner 1% Oral Solution