Antiparasitic
Antiparasitic
LEVOZAND® 7.5
Levamisole Hydrochloride Oral Solution 7.5%
Composition
| Ingredient | Amount | Unit |
|---|---|---|
| Each ml of LEVOZAND® 7.5 contains : | ||
| levamisole hydrochloride | 75 | mg |
Mechanism of action
Levamisole is an anthelmintic of the imidazothiazole group. Its antiparasitic activity is mediated primarily by stimulation of nicotinic acetylcholine receptors (nAChRs) in nematodes. By binding to and activating these receptors in the parasite’s neuromuscular system, levamisole causes sustained depolarization and muscle contraction, resulting in spastic paralysis of the nematode. The paralyzed worm can no longer maintain its position in the gastrointestinal tract or other sites of residence and is expelled by normal gastrointestinal motility.
Target species
Poultry, cattle, sheep, and goats
Indications
Levamisole is used for the treatment and control of parasitic gastroenteritis and respiratory disease caused by susceptible nematodes, including adult and developing immature stages, in livestock and poultry. In livestock, it is effective against gastrointestinal nematodes, including Haemonchus, Ostertagia, Trichostrongylus, Cooperia, Nematodirus, Bunostomum, Oesophagostomum, and Chabertia, and lungworms of the genus Dictyocaulus. In poultry, levamisole is also used to treat and control infections caused by susceptible gastrointestinal nematodes, including Ascaridia galli and Heterakis gallinarum; activity against certain Capillaria species has also been reported.
Packaging
1 liter Polyethylene bottles
Storage Conditions
Store below 25°C, protected from direct light, in the original packaging. After opening, keep the container cap tightly closed. Protect from freezing.
Dosage and Administration
Cattle, sheep, and goats
Administer 7.5 mg of levamisole per kg of body weight, equivalent to 1 ml of LEVOZAND® 7.5 per 10 kg of body weight, by direct oral drench using a drenching gun or a syringe without a needle.
For cattle weighing more than 300 kg, add 1 ml for each additional 10 kg of body weight. For sheep weighing more than 60 kg, add 0.5 ml for each additional 5 kg of body weight.
In pregnant ewes, if advised by a veterinarian, treatment may be given approximately 6 weeks before lambing and again at weaning.
Poultry
For control and treatment of nematode infections
Administer 20 to 30 mg of levamisole per kg of body weight, or 1 to 1.5 liters of LEVOZAND® 7.5 per 1000 liters of drinking water, for 1 day; repeat treatment after 21 days.
For immune stimulation
Administer 20 to 30 mg of levamisole per kg of body weight, or 1 to 1.5 liters of LEVOZAND® 7.5 per 3000 liters of drinking water, for 3 days; repeat treatment after 3 days.
- As directed by a veterinarian.
Administer 7.5 mg of levamisole per kg of body weight, equivalent to 1 ml of LEVOZAND® 7.5 per 10 kg of body weight, by direct oral drench using a drenching gun or a syringe without a needle.
For cattle weighing more than 300 kg, add 1 ml for each additional 10 kg of body weight. For sheep weighing more than 60 kg, add 0.5 ml for each additional 5 kg of body weight.
In pregnant ewes, if advised by a veterinarian, treatment may be given approximately 6 weeks before lambing and again at weaning.
Poultry
For control and treatment of nematode infections
Administer 20 to 30 mg of levamisole per kg of body weight, or 1 to 1.5 liters of LEVOZAND® 7.5 per 1000 liters of drinking water, for 1 day; repeat treatment after 21 days.
For immune stimulation
Administer 20 to 30 mg of levamisole per kg of body weight, or 1 to 1.5 liters of LEVOZAND® 7.5 per 3000 liters of drinking water, for 3 days; repeat treatment after 3 days.
- As directed by a veterinarian.
Withdrawal period
Poultry: 10 days
Cattle: 14 days
Sheep and kids: 21 days
Cattle: 14 days
Sheep and kids: 21 days
Contraindications
Do not use in animals whose milk is intended for human consumption.
Do not use in laying hens producing eggs for human consumption.
Do not use in laying hens producing eggs for human consumption.
Precautions
Do not exceed the recommended dose of LEVOZAND® 7.5 Signs of levamisole toxicity may include increased salivation, hyperexcitability, tremors and muscle contractions, head shaking, impaired locomotion, dyspnea, increased urination and defecation, and, in severe cases, collapse and death.
In poultry, LEVOZAND® 7.5 toxicity may be associated with depression, ataxia, and paralysis of the wings or legs.
Medicated drinking water should be consumed within 24 hours.
Do not eat, drink or smoke when handling this product.
Keep out of reach of children.
In poultry, LEVOZAND® 7.5 toxicity may be associated with depression, ataxia, and paralysis of the wings or legs.
Medicated drinking water should be consumed within 24 hours.
Do not eat, drink or smoke when handling this product.
Keep out of reach of children.
Drug interactions
Avoid Concomitant use of LEVOZAND® 7.5 with florfenicol.
Concomitant use of LEVOZAND® 7.5 with drugs having nicotinic activity, such as pyrantel, morantel, and diethylcarbamazine, and with cholinesterase inhibitors, particularly organophosphorus compounds, is not recommended because of the risk of increased levamisole toxicity.
Concomitant use of LEVOZAND® 7.5 with drugs having nicotinic activity, such as pyrantel, morantel, and diethylcarbamazine, and with cholinesterase inhibitors, particularly organophosphorus compounds, is not recommended because of the risk of increased levamisole toxicity.
Levamisole Hydrochloride Oral Solution 7.5%