Therapeutic support
Therapeutic support
Orsozand®
Oral Rehydration Salts (ORS) Water-Soluble Powder
Composition
| Ingredient | Amount | Unit |
|---|---|---|
| Each gram of Orsozand® contains: | ||
| Sodium chloride | 145 | mg |
| Potassium chloride | 40 | mg |
| Trisodium citrate | 165 | mg |
| Dextrose | 650 | mg |
Mechanism of action
Sodium is the principal extracellular cation responsible for maintaining osmotic pressure and extracellular fluid volume. It is essential for neuromuscular excitability, nerve impulse transmission, and intestinal nutrient transport through Na⁺-dependent glucose and amino acid cotransporters. Sodium also plays a central role in acid–base balance through renal handling and influences water intake and appetite.
Chloride is the major extracellular anion that balances sodium in plasma and contributes to the maintenance of osmotic equilibrium. It is involved in renal acid–base regulation and is essential for the chloride shift in red blood cells.
Potassium is the major intracellular cation and is crucial for maintaining membrane potential, normal nerve and muscle function, and cellular metabolism. It is involved in carbohydrate metabolism and enzyme activation and influences water balance and nutrient uptake. Trisodium citrate acts as a buffering agent to help correct metabolic acidosis associated with dehydration. Its role extends beyond simply providing sodium. Following absorption, citrate is metabolized to bicarbonate in the body, which helps counteract the metabolic acidosis resulting from bicarbonate loss during diarrhea. Dextrose, also known as D-glucose, is a simple monosaccharide and a primary source of energy for cellular metabolism. Dextrose stimulates the intestinal sodium/glucose cotransporter (SGLT1), which plays a crucial role in fluid absorption. SGLT1 is a sodium-dependent, glucose-dependent transporter that facilitates the uptake of glucose and sodium ions into intestinal cells, thereby promoting water absorption. This mechanism is particularly effective in the treatment of dehydration associated with diarrhea.
Collectively, this balanced combination of sodium, potassium, chloride, citrate, and dextrose effectively rehydrates, restores essential electrolytes, assists in correcting acid-base disturbances, and provides vital caloric support.
Chloride is the major extracellular anion that balances sodium in plasma and contributes to the maintenance of osmotic equilibrium. It is involved in renal acid–base regulation and is essential for the chloride shift in red blood cells.
Potassium is the major intracellular cation and is crucial for maintaining membrane potential, normal nerve and muscle function, and cellular metabolism. It is involved in carbohydrate metabolism and enzyme activation and influences water balance and nutrient uptake. Trisodium citrate acts as a buffering agent to help correct metabolic acidosis associated with dehydration. Its role extends beyond simply providing sodium. Following absorption, citrate is metabolized to bicarbonate in the body, which helps counteract the metabolic acidosis resulting from bicarbonate loss during diarrhea. Dextrose, also known as D-glucose, is a simple monosaccharide and a primary source of energy for cellular metabolism. Dextrose stimulates the intestinal sodium/glucose cotransporter (SGLT1), which plays a crucial role in fluid absorption. SGLT1 is a sodium-dependent, glucose-dependent transporter that facilitates the uptake of glucose and sodium ions into intestinal cells, thereby promoting water absorption. This mechanism is particularly effective in the treatment of dehydration associated with diarrhea.
Collectively, this balanced combination of sodium, potassium, chloride, citrate, and dextrose effectively rehydrates, restores essential electrolytes, assists in correcting acid-base disturbances, and provides vital caloric support.
Target species
Large animals
Indications
Orsozand® is indicated for the restoration of lost fluids and electrolytes and the provision of energy in calves, lambs, and goats, specifically under the following conditions:
• Dehydration and diarrhea arising from gastrointestinal disorders.
• Replenishment of fluid and electrolyte losses during convalescence following systemic or digestive infections.
• Conditions associated with reduced feed and water intake, accompanied by heightened metabolic demand for energy and electrolytes.
• Environmental and management-related stress, including transportation, regrouping, and heat stress, to maintain fluid balance and homeostasis.
• Adjunctive support in correcting mild to moderate metabolic acidosis associated with gastrointestinal fluid losses.
• Dehydration and diarrhea arising from gastrointestinal disorders.
• Replenishment of fluid and electrolyte losses during convalescence following systemic or digestive infections.
• Conditions associated with reduced feed and water intake, accompanied by heightened metabolic demand for energy and electrolytes.
• Environmental and management-related stress, including transportation, regrouping, and heat stress, to maintain fluid balance and homeostasis.
• Adjunctive support in correcting mild to moderate metabolic acidosis associated with gastrointestinal fluid losses.
Packaging
100 g multilayer aluminium sachets
Storage Conditions
Store in a dry place below 25°C, protected from direct light, in the original packaging. Once opened, keep the sachet tightly closed.
Dosage and Administration
Dissolve 25 g of Orsozand® in 1 liter of drinking water. Administer 1 to 1.5 liters of the prepared oral rehydration solution per animal (adjusted according to body weight), 3 times daily for 3 to 4 consecutive days.
- As directed by a veterinarian.
- As directed by a veterinarian.
Withdrawal period
Meat and offal: 0 days
Milk: 0 days
Milk: 0 days
Contraindications
Do not administer to animals suffering from complete mechanical gastrointestinal tract obstruction.
Precautions
• In cases of severe gastrointestinal obstruction, profound dehydration, or hypovolemic shock, parenteral fluid and electrolyte therapy must be instituted.
• Medicated drinking water should be used within 24 hours.
• Keep out of reach of children.
• Medicated drinking water should be used within 24 hours.
• Keep out of reach of children.
Drug interactions
No known drug interactions have been reported at the recommended dosage.
Oral Rehydration Salts (ORS) Water-Soluble Powder