Antibiotic solution
Antibiotic solution
Enrozand®
Enrofloxacin 10% Oral Solution
Composition
| Ingredient | Amount | Unit |
|---|---|---|
| Each ml of Enrozand® contains : | ||
| enrofloxacin | 100 | mg |
Mechanism of action
Enrofloxacin is a synthetic antibiotic belonging to the fluoroquinolone class and is classified as a second-generation fluoroquinolone. Its bactericidal activity is concentration-dependent, with increasing drug exposure, particularly effective drug concentrations, resulting in enhanced antibacterial activity.
Enrofloxacin inhibits the bacterial enzymes DNA gyrase (Topoisomerase II) and Topoisomerase IV, thereby disrupting bacterial DNA replication and transcription and ultimately resulting in bacterial cell death.
Enrofloxacin may exhibit a post-antibiotic effect (PAE) and can exert antibacterial activity against bacteria during both the growth phase and stationary phase.
Enrofloxacin has a broad spectrum of activity against many Gram-negative bacteria, including Escherichia coli, Salmonella spp., Pseudomonas spp., Pasteurella spp. and Avibacterium spp., as well as certain Gram-positive bacteria, such as Staphylococcus spp. It is also active against Mycoplasma spp.
Enrofloxacin inhibits the bacterial enzymes DNA gyrase (Topoisomerase II) and Topoisomerase IV, thereby disrupting bacterial DNA replication and transcription and ultimately resulting in bacterial cell death.
Enrofloxacin may exhibit a post-antibiotic effect (PAE) and can exert antibacterial activity against bacteria during both the growth phase and stationary phase.
Enrofloxacin has a broad spectrum of activity against many Gram-negative bacteria, including Escherichia coli, Salmonella spp., Pseudomonas spp., Pasteurella spp. and Avibacterium spp., as well as certain Gram-positive bacteria, such as Staphylococcus spp. It is also active against Mycoplasma spp.
Target species
Broilers, Breeders and Turkeys
Indications
Enrozand® is indicated for the treatment of infections caused by microorganisms susceptible to enrofloxacin, including colibacillosis, salmonellosis, pasteurellosis, infectious coryza, and Mycoplasma-associated chronic respiratory disease (CRD).
Packaging
1 L polyethylene bottles
Storage Conditions
Store below 25°C, protected from direct light, in the original packaging. After opening, keep the container cap tightly closed. Protect from freezing.
Dosage and Administration
10 to 20 mg of enrofloxacin per kg of body weight equivalent to 1 to 2 ml of Enrozand® per 10 kg of body weight, or 500 to 1000 ml of Enrozand® in 1000 liters of drinking water for 3 to 5 consecutive days.
It is recommended that in mixed infections and the chronic form of the disease, 1000 ml of Enrozand® in 1000 liters of drinking water be used for 5 consecutive days.
– As directed by a veterinarian.
It is recommended that in mixed infections and the chronic form of the disease, 1000 ml of Enrozand® in 1000 liters of drinking water be used for 5 consecutive days.
– As directed by a veterinarian.
Withdrawal period
Broilers: 9 days
Turkeys: 11 days
Turkeys: 11 days
Contraindications
Do not use in laying hens producing eggs for human consumption.
Precautions
Medicated drinking water should be used within 24 hours.
Keep out of reach of children.
Keep out of reach of children.
Drug interactions
Concomitant use of Enrozand® with florfenicol, tetracyclines and macrolides is not recommended due to antagonistic effects.
The effect of Enrozand® may be reduced in the presence of divalent and trivalent cations such as iron, calcium and magnesium.
The effect of Enrozand® may be reduced in the presence of divalent and trivalent cations such as iron, calcium and magnesium.
Enrofloxacin 10% Oral Solution